题   目：From phosphorus metallo-dendrimers to polycationic dendrimers and dendrons as original nanoplatforms to treat cancers and tuberculosis: Main progress
 报告人：Serge Mignani 教授
             Université Paris Descartes
 时   间：2018年4月10日（星期二）9:30
 地   点：四号学院楼3083室
 主持人：史向阳  教授

 报告人简介：

     Serge Mignani - Formerly Head of Medicinal Chemistry Department and Scientific Director (Sanofi)- Université Paris Descartes, PRES Sorbonne Paris Cité, CNRS, UMR 860, Laboratoire de Chimie et Biochimie pharmacologiques et toxicologiques, 45 rue des Saints Pères, 75006, Paris, France- CQM - Centro de Química da Madeira, MMRG, Universidade da Madeira, Campus da Penteada, 9020-105 Funchal, Portugal

 报告内容简介：

     The focus of this presentation will be to present and analyze the development of metallo-phosphorus dendrimers as new anticancer agents with original mechanism of action. Based on these anticancer activities, we developed original polycationic phosphorus dendrimers and dendrons as new anticancer agents. Interestingly, several of them, but with different chemical structure, showed antimycobacterial activities as first-in-class agents against tuberculosis. In addition, main structure-activity relationships will be also presented for the different chemical series related to biological activities.